Which Works Better for Knee Osteoarthritis—PRP or Hyaluronic Acid? An Evidence-Based Perspective
One of the main causes of persistent joint pain and functional impairment, particularly in middle-aged and older people, is knee osteoarthritis (OA). Physiotherapy, medication, and lifestyle changes are usually part of the initial management. But as the illness worsens, a lot of patients look for injectable treatments to reduce pain and increase mobility. Injections of Hyaluronic Acid (HA) and Platelet-Rich Plasma (PRP) are two of the most popular choices among them. Therefore, the relevant question is: which of these treatments is more effective in clinical settings? Let’s look at the proof.
What Are PRP and HA Injections?
“HA” is a gel-like fluid that acts as a lubricant and natural shock absorber within the joint. In osteoarthritis (OA), HA decreases, and joints become painful and stiff. Injection of HA seeks to replace this lubrication and reduce friction. PRP, however, is extracted from the blood of the individual. It’s processed to concentrate platelets, which are rich in growth factors that promote tissue repair and reduce inflammation. In theory, PRP does more than simply provide joint lubrication – it promotes the body’s natural healing process.
What Does the Research Say?
A number of clinical studies and meta-analyses in recent years have pitted the two treatments against one another. The evidence also indicates that PRP provides better long-term results compared to HA.
Particularly after 6 to 12 months of treatment, PRP truly shines when it comes to reducing pain and enhancing function. Although HA injections may offer some temporary respite, their effects usually subside within a few months.
For example, a 2023 systematic review published in The American Journal of Sports Medicine found that PRP was superior to HA for reducing pain and improving knee function at both 6 and 12 months. Additionally, PRP may be able to slow down the degeneration of cartilage in the early stages of osteoarthritis.
Choosing the Best Course of Treatment
Despite its apparent superior results, Platelet-Rich Plasma (PRP) therapy is more expensive and frequently requires several treatment sessions. On the other hand, injections of hyaluronic acid (HA) are a dependable and proven substitute that has a good safety record and few side effects. However, PRP therapy typically shows higher overall benefit for those looking for longer-lasting symptom relief and improved joint function.
In conclusion
Injections of Hyaluronic Acid (HA) and Platelet-Rich Plasma (PRP) have both shown some promise in reducing knee osteoarthritis symptoms. Current research, however, tends to support PRP therapy for patients looking for longer-lasting pain relief and possible assistance with joint repair. It is still crucial to consult an orthopedic specialist at the Orthobiologix Clinic in Mumbai before making any treatment decisions, taking into account the patient’s age, disease severity, and overall health.
Disclaimer: The information on this site is just meant to be used for learning and general knowledge. It does not take the place of professional medical advice, diagnosis, or care. If you need personalised medical advice, go to a diagnostic centre or talk to a qualified healthcare practitioner.
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